Research and Development of Donepezil Hydrochloride, a New Type of Acetylcholinesterase Inhibitor
نویسندگان
چکیده
منابع مشابه
Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor.
A wide range of evidence shows that cholinesterase (ChE) inhibitors can interfere with the progression of Alzheimer's disease (AD). The earliest known ChE inhibitors, namely, physostigmine and tacrine, showed modest improvement in the cognitive function of AD patients. However, clinical studies show that physostigmine has poor oral activity, brain penetration and pharmacokinetic parameters, whi...
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چکیده ندارد.
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
A wide range of evidence shows that acetylcholinesterase (AChE) inhibitors can interfere with the progression of Alzheimer's disease (AD). The successful development of these compounds was based on a well-accepted theory that the decline in cognitive and mental functions associated with AD is related to the loss of cortical cholinergic neurotransmission. The earliest known AChE inhibitors, name...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2002
ISSN: 0021-5198
DOI: 10.1254/jjp.89.7